The following is the summary of a recent study of Platelet Rich Plasma in the treatment of osteoarthritis of the knee.
Alberto Gobbi, MD,* Georgios Karnatzikos, MD, Vivek Mahajan, MD, and Somanna Malchira, MD
Background: With increasing frequency, platelet-rich plasma (PRP) preparations have been used to treat cartilage lesions to regenerate tissue homeostasis and retard the progression of knee osteoarthritis (OA).
Purpose: To determine the effectiveness of intra-articular PRP injections in active patients with knee OA and to evaluate clinical outcomes in patients with and without previous surgical treatment for cartilage lesions.
Study Design: Case series.
Materials and Methods: Fifty patients with knee OA were followed for a minimum of 12 months. All were treated with 2 intra-articular injections of autologous PRP. Twenty-five patients had undergone a previous operative intervention for cartilage lesions, whereas 25 had not. Operated patients had undergone either cartilage shaving or microfracture. Multiple evaluative scores were collected at pretreatment and at 6 and 12 months posttreatment. The required sample of patients was determined beforehand by using statistical power analysis; International Knee Documentation Committee (subjective) score was defined as the primary parameter. A P value of less than 0.05 was considered statistically significant. General linear model–repeated measure test evaluated within-time improvement for each variable for all patients. Post hoc test with Bonferroni adjustment for multiple comparisons was performed to investigate the significance in improvement within time evaluations for each variable for the total sample. The differences in improvement between operated and non operated patients were also investigated, as were those between sexes.
Results: All patients showed significant improvement in all scores at 6 and 12 months (P < 0.01) and returned to previous activities. No significant difference in improvement was found between the evaluated subgroups (P < 0.01).
Conclusions: The PRP treatment showed positive effects in patients with knee OA. Operated and non operated patients showed significant improvement by means of diminishing pain and improved symptoms and quality of life.
Clinical Relevance: There are only a few studies of PRP treatment for cartilage on osteoarthritic knees. Different PRP products might be more or less appropriate to treat different types of tissues and pathologies. The clinical efficacy of PRP remains under debate, and a standardized protocol has not yet been established.
Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
We have recently added Platelet Rich Plasma treatments to the services we provide at SCMC. This involves using the patient’s own growth factors to stimulate healing and rejuvenation. A small blood sample is taken and placed in a special tube. The various components are separated by centrifugation and the platelet fraction isolated for therapeutic use.
The platelet component of blood contains a range of growth factors. These can be utilised in a variety of cosmetic and musculoskeletal settings.
In the cosmetic context, we can rejuvenate ageing skin by stimulating collagen production, stem cell migration, differentiation and proliferation and stimulation of new blood vessels, nutrients and the other components of the extracellular matrix.
PRP also has a variety of musculoskeletal applications. By enhancing the healing cascade right at the source of the problem, we can treat conditions such as tennis elbow, plantar fasciitis, jumpers knee and other tendinopathies, as well as degenerative and arthritic conditions.
Contact us now for more information on this and our various other treatments.